Abstract
The present study was planned in order to investigate the effects of various oral doses of water extract of <em>Syzygium aromaticum</em> buds, emphases of its effect were placed on changes of the growth, serological, hematological and pathological characteristics of Wistar rats. Water extract of <em>Syzygium aromaticum</em> was fed to Wistar rats at 50, 200, 400 and 800 mg/kg/day for two weeks. Impairment of growth and hepatonephrotoxicity were observed in the rats of all groups. These changes were correlated with alterations in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) activities and total protein, cholesterol and urea concentration and hematology.
Highlights
Cloves are the dried flower buds of Syzygium aromaticum (L.) Merr& Perry, a tree of the myrtle family (Myrtaceae), which is an evergreen tropical plant that flowers twice every year and harvested when the outer green leaves have changed from green to a yellow pink (Fig. 1)
Serobiochemical parameters: Serum samples were Analyzed for the activities of Aspartate Transaminase (AST), Alanine transaminase (ALT), Alkaline phosphatase (ALP) and for concentration of total protein, albumin, globulin, bilirubin, cholesterol and urea
Haematological methods: Whole blood for hematological parameter collected in EDTA anticoagulant blood container and examined for Haemoglobin (Hb), Packed Cell Volume (PCV), Red Blood Cells (RBCs), white blood cells (WBCs) and differential White Blood cells (WBCs) count, Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin (MCH) and mean Corpuscular Haemoglobin Concentration (MCHC) and the measuring techniques were performed according to an Automated Hematology Analyzer (Human GambH, Max-Planck-Ring 21,D-65205 Wiesbaden, Germany)
Summary
Cloves are the dried flower buds of Syzygium aromaticum (L.) Merr& Perry, a tree of the myrtle family (Myrtaceae), which is an evergreen tropical plant that flowers twice every year and harvested when the outer green leaves (calyx) have changed from green to a yellow pink (Fig. 1). It has been grown in Indonesia, India, Malaysia and Sri Lanka, but production in the Asian countries is quite small as compared to that in countries in other regions, namely Madagascar, Tanzania (especially in Zanzibar) and the West Indies (Chomchalow, 1996). It is used in many therapeutic fields such the treatment of kidney and intestinal diseases, against impotence, genital-pain and infertility and is reported as stomachic (Nadkarni, 2000) and has smooth muscle relaxant property (Damiani et al, 2003)
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