Abstract
Objective: To verify the reduction of the central blood pressure and vascular resistance in hypertensive patients treated with angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), isolated or in association. Design and method: Retrospective cohort, in which the peripheral blood pressure of the 346 hypertensive patients was the average of three measurements in the office, following the guidelines of the Brazilian Hypertension Guidelines. The central pressure parameters were verified by the oscillometric method with the Mobil-O-Graph® equipment, with triple shot protocol. The diagnosis of hypertension was determined by the use of antihypertensive drugs. Individuals using ACE inhibitors or ARBs in isolated or combined therapy of both genders, aged over 18 years, were selected. Results: The sample had a mean age of the 56.8 ± 15.5 years. The prevalence of overweight was 41.6%, obesity 39.4%, smoking 3.9%, sedentary lifestyle 52.8%, diabetes 20.2% and dyslipidemia 65.7%. Peripheral systolic blood pressures (125.3 - 128.3 mmHg, p = 0.097) were similar in the ACE inhibitors and ARBs groups, while diastolic blood pressures were different intergroups. The central blood pressure was lower in the ACE inhibitors group when compared to the ARBs group (114.6 - 117.6 mmHg, p = 0.067). Regarding peripheral vascular resistance (1.18 - 1.23 units, p = 0.032), the ACE inhibitors group showed greater compliance. Conclusions: Therefore, this cohort presented mean peripheral blood pressures within the goals recommended by the guidelines, and a significant difference in vascular resistance.
Published Version
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