Abstract
Effects of repeated daily intracerebroventricular injections of 1 μg of glucagon-like peptide-1 (7–36) amide (tGLP-1) on feeding and drinking behaviour, as well as neurohypophysial hormone secretion, was investigated in rats drinking tap water or 2% saline for 6 days. In euhydrated rats, tGLP-1 decreased moderately food and water consumption without a marked reduction of body weight. In salt-loaded rats, tGLP-1 considerably inhibited saline intake. On the other hand, food consumption and body weight changes were similar in vehicle- and tGLP-1-treated rats drinking 2% saline. Osmotic stimulation resulted in the augmented release of both neurohypophysial hormones. tGLP-1 did not alter plasma vasopressin and oxytocin concentrations either in euhydrated or osmotically stimulated rats. It is concluded that tGLP-1 may modify feeding and drinking behaviour under conditions of normal or disturbed water–electrolyte balance in the rat.
Published Version
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