Abstract
The effect of oxytetracycline and demethylchlortetracycline on aldosterone- and insulin-mediated Na + transport (short-circuit current) were examined in toad urinary bladders mounted in modified Ussing chambers. Oxytetracycline had little or no effect on either basal or aldosterone-mediated Na + transport. In contrast, demethylchlortetracycline markedly inhibited both basal and aldosterone-mediated Na + transport. Furthermore, demethylchlortetracycline inhibited the aldosterone response significantly out of proportion to its effects on basal Na + transport. Neither of the drugs had an effect on insulin-mediated Na + transport. Consequently, the natriuresis observed in certain patients treated with demethylchlortetracyline may be related to drug-induced renal resistance to the effects of aldosterone.
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