Abstract
Hyperuricemia, as a critical risk factor for various adverse clinical outcomes, shows a trend of increasing prevalence among young-aged population. Dietary adjuvant therapy by function foods, such as tart cherry, is promising. Thus, effects of tart cherry powder specialized in hyperuricemia were explored via establishing a hyperuricemia model in Sprague Dawley rats by cotreatment with oteracil potassium and adenine. The results indicated that low dose of tart cherry powder (0.17 g/kg·bw) showed effects on hyperuricemia by slightly decreasing serum uric acid and improving kidney injury, whereas high dose of tart cherry powder (0.50 g/kg·bw) could merely alleviate kidney injury. Meanwhile, adenosine deaminase activity rather than xanthine oxidase activity was affected at low dose, which reveals low dose of tarty cherry powder may be beneficial to hyperuricemia through reduction of ADA activity, and its reported potentials on antioxidation or anti-inflammation provide clues for further study.
Highlights
Hyperuricemia is a metabolic disorder diagnosed as overproduction of the serum uric acid level, that is, >357 mmol/L in females and >416 mmol/L in males [1], which pathophysiologically results from renal less excretion mainly [2] and overproduction of uric acid [3]
Kidney injury in this model was caused by the separation and deposition of urate crystals, which was similar to the renal injury of primary hyperuricemia implicated in pathological states such as gout and inherited purine disorders
Our study demonstrates the tart cherry powder at low dose showed limited protecting effects on hyperuricemia by slightly decreasing serum uric acid at the early stage of hyperuricemia and improving kidney injury
Summary
Hyperuricemia is a metabolic disorder diagnosed as overproduction of the serum uric acid level, that is, >357 mmol/L in females and >416 mmol/L in males [1], which pathophysiologically results from renal less excretion mainly (about 90%) [2] and overproduction of uric acid [3]. Two epidemiological studies suggested that tart cherry could decrease serum uric acid in healthy population [18] or overweight/ obese adults [15]. An animal study of 2 weeks showed that tart cherry juice treatment reduced the serum uric acid levels in hyperuricemic rats in a time-dependent manner [19]. Ese results implied the potential on improving hyperuricemia as well as exhibited a limitation that presents evidence is lacking in hyperuricemia population for a long treatment by tart cherry. Is study aims to explore the long-term effects of tart cherry powder on the progressive hyperuricemia and the secondary renal and liver injury comparing with classical medicine effects in hyperuricemic rats caused by oteracil potassium and adenine Establishing a steady hyperuricemia rat model and exploring the benefits of tart cherry for hyperuricemia are more feasible. is study aims to explore the long-term effects of tart cherry powder on the progressive hyperuricemia and the secondary renal and liver injury comparing with classical medicine effects in hyperuricemic rats caused by oteracil potassium and adenine
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