Effects of sufentanil and fentanyl on patients with controlled intravenous analgesia

Abstract

Objective To compare the efficacy of sufentanil and fentanyl on patients with conteolled intravenous analgesia postoperatively.Methods A total of 60 ASA Ⅰ - Ⅱ patients underwent elective abdominal surgery were randomly divided into sufentanil group and fentanyl group( n =30 for each group).The loading dose for patient controlled intravenous analgesia(PCIA) in both groups was fentany1 0.02 mg and droperido1 1.5mg.Postoperative analgesia was obtained by a patient-controlled intravenous pump.Patients in the sufentanil group were received sufentanil 0.1mg with sodium chloride injection 100ml,and patients in the fentanyl group were received fentanyl 1.0mg with sodium chloride injection 100ml.The visual analog scale ( VAS),Ramsay scale,patient satisfaction and adverse reactions were investigated 48h after operation.Results VAS scores at 4,8h after operation in the sufentanil group were lower than those in the fentanyl group(all P ＜0.05).Ramsay scale scores in the sufentanil group were higher than those in the fentanyl group( all P ＜0.05 ).There were no significant differences in PCIA pressing times and adverse reactions between the two groups ( all P ＞ 0.05 ).Conclusion Intravenous postoperative analgesia with sufentanil had better analgesic effect and stronger sedation effect than equivalent dose of fentanyl. Key words: Sufentanil; Fentanyl; Analgesia, patient-controlled