Abstract
The effects of substance P nonapeptide amide on inactivation of substance P by the guinea-pig ileum and urinary bladder preparations and of substance P hexapeptide amide, bradykinin and acetylcholine by the guinea-pig urinary bladder, have been investigated. Significant inhibition of inactivation of Substance P was found only in the urinary bladder. None of the other agents were significantly affected. These results suggest that the previously reported agonist effects of substance P nonapeptide may be due to inhibition of inactivation of SP in vivo and this effect is possibly specific.
Published Version
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