Abstract
The combined action of polyene macrolid antibiotic amphotericin B and styryl dye RH 421 in model lipid membranes and in yeast Saccharomyces cerevisiae is studied. Addition of RH 421 to ergosterol-containing lipid bilayers leads to an increase by 8.5 ±3.2 times of the equilibrium number of open amphotericin channels. The agar-diffusion method shows that RH 421 enhances the antimicrobial effect of amphotericin B, leading to an increase by 1.5 times of the zone of growth inhibition of S. cerevisiae strain. Our data suggest that RH 421 is a potential synergist of amphotericin B and can be used in novel drugs with improved pharmacological properties.
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