Abstract
Intravenous streptozotocin, 50 mg/kg, caused a marked rise in blood glucose, FFA and ketone bodies 3 hr after administration to 48-hr starved rats. At 7 hr the animals were hypoglycemic with falls in blood ketone bodies and FFA and a rise in blood pyruvate. At 48 hr the rats were irreversibly hyperglycemic (326 ± 16 mg/100 ml compared with 80±3 mg/100 ml) but presented normal fasting concentrations of blood ketone bodies, lactate and pyruvate. Liver glycogen was elevated at 3 hr and reached 62.5 mg/g at 7 hr, which was followed by a decrease to fasting concentrations. 3,5-Dimethylpyrazole, an antilypolytic agent, and nicotinamide, which protects against the effects of streptozotocin, both attenuated or prevented the rise in FFA seen at 3 hr with streptozotocin without affecting the reduction in serum insulin caused by streptozotocin. Plasma FFA and blood ketone bodies were reduced to below fasting control values. Liver ketone body levels showed changes similar to those found in blood. It is suggested that...
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