Abstract
BackgroundPatients with Type 2 diabetes (T2DM) are prone to develop dementia. Results from a recent study indicated that statin users had lower chance of developing incident dementia. However there is little information on the potential benefits of statin use on dementia in patients with T2DM cohort.MethodA population-based retrospective study using a nationwide cohort of National Health Insurance Research Database in Taiwan was performed. T2DM cohort with regular use of statins was followed up to 8 years. Multivariate cox-proportional hazards regression model was used to estimate the association between statin use and incidence of dementia including Alzheimer's disease and non-Alzheimer dementia after adjusting for several potential confounders.ResultsAmong 28,321 patients diagnosed with T2DM age above 50 and without history of dementia before 2000/1/1, 15,770 patients who had never used statin and 2,400 patients who regularly used statin drugs were enrolled. After adjusting for age group, gender, CCI (Charlson-Deyo comorbidity index) group, stroke types and anti-diabetic drugs, regular statin use was associated with a decreased risk of developing incident Alzheimer's disease dementia (adjusted HR: 0.48, 95% CI 0.30 – 0.76, p<0.001), but not in non-Alzheimer dementia (adjusted HR: 1.07, 95% CI 0.54–2.12 p = 0.844) in patients with T2DM. Further analysis showed significant protective effects of the use of atorvastatin and simvastatin.ConclusionRegular use of statins might decrease the risk of developing Alzheimer's disease in patients with T2DM while no benefit was observed in non-Alzheimer dementia. Among statins, both atorvastatin and simvastatin showed significant benefits.
Highlights
Among 28,321 patients diagnosed with type 2 diabetes mellitus (T2DM) age above 50 and without history of dementia before 2000/1/1, 15,770 patients who had never used statin and 2,400 patients who regularly used statin drugs were enrolled
After adjusting for age group, gender, Charlson comorbidity index (CCI) (Charlson-Deyo comorbidity index) group, stroke types and anti-diabetic drugs, regular statin use was associated with a decreased risk of developing incident Alzheimer’s disease dementia, but not in non-Alzheimer dementia in patients with T2DM
It is well recognized that people with diabetes have a greater decline in cognitive function and a higher risk of developing dementia [1], some studies declared that the relation between diabetes and major types of dementia remains controversial [2]
Summary
It is well recognized that people with diabetes have a greater decline in cognitive function and a higher risk of developing dementia [1], some studies declared that the relation between diabetes and major types of dementia remains controversial [2]. A large body of researches reported that diabetes may increase the risk of Alzheimer’s disease as well as vascular dementia in both sexes and in all ages [3,4,5,6]. Patients with Type 2 diabetes (T2DM) are prone to develop dementia. Results from a recent study indicated that statin users had lower chance of developing incident dementia. There is little information on the potential benefits of statin use on dementia in patients with T2DM cohort
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