Abstract
Ten kinds of dibucaine salts were prepared. Effects of some counter ions on effective duration of surface anesthesia with dibucaine base on the rabbit cornea were studied, with reference to their effects on physicochemical properties of the base. Solvent affinity of dibucaine base, especially solubility in water and distribution ratio between chloroform and water were found to be influenced by the presence of counter ions. It seemed that the change in solvent affinity was influenced by the change of hydrolytic constant of dibucaine salts. Logarithmic plots of effective duration against distribution ratio revealed a significant correlation coefficient of r=0.81. It was demonstrated that the higher the distribution ratio, the longer the effective duration.
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Schedule a callMore From: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
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