Abstract
The effects of members of the three main groups of cancer-chemotherapeutic agents: hormones, antimetabolites and alkylating agents, on a previously described SV 40 induced rat sarcoma were studied. Tumour cells were grown in vitro and inoculated into young non-inbred rats. In the initial experiment, when the agents were given 24 hours after inoculation of tumour cells cultured in vitro, the tumour take was prevented to a statistically significant degree by the two alkylating agents, cyclophosphamide and thiotepa. The effects of hydrocortisone, fluorouracil and azathioprine were not statistically significant. In the subsequent experiments therefore, only alkylating agents were employed. Combination with 200 R total body X-ray irradiation caused a high mortality. Cyclophosphamide, which had shown the best effect in previous experiments, was also used for the treatment of palpable tumours. Their growth was retarded, so that a highly significant difference in tumour size as compared to controls was obtained. There was no increase in definitive cures, however. In final experiments, the highly protective effect of cyclophosphamide was verified. Most of the cyclophosphamide-treated rats without tumours died with progressive wasting after several weeks.
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