Abstract
Weanling NZB/NZW F1 (B/W) mice were treated with sex steroid hormones in an attempt to modify their spontaneous autoimmune disease. Dihydrotestosterone (DHT) improved survival, whereas 17-β-estradiol (E2) or DHT plus E2 reduced survival. The latter combination was more lethal than E2 alone. Survival was accompanied by decreased concentrations of antibodies to DNA and polyadenylic acid, and less evidence of renal disease. Mice treated with E2, or DHT plus E2, had higher concentrations of autoantibodies, more severe renal disease, and reduced responses to phytohemagglutinin (PHA) and Concanavalin A (Con A).
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