Abstract
Recent studies (1-3) have shown that when myelinated, organotypic cultures of central nervous system (CNS) tissue are exposed to heated (complement-inactivated) anti-whole CNS antiserum from rabbits with acute experimental allergic encephalomyelitis (EAE), myelin sheaths are not destroyed, but oligodendroglia are stimulated to produce profuse, aberrant arrays of their processes and the periodicity of myelin sheaths acquires a unique morphology. The same serum in the presence of complement demyelinates the tissue within the first few hours of exposure (4, 5). In addition, there appears to be a specific effect of EAE serum on CNS elements. These changes are associated with the binding of antibody to the myelin sheaths (6). To test whether similar abnormalities could be induced in the peripheral nervous system (PNS), the present study involved cultures of PNS and CNS tissue exposed to heated and unheated serum from rabbits with experimental allergic neuritis (EAN), induced by challenge with PNS tissues in complete Freund’s adjuvant (CFA).
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