Abstract
1. 1. The effects of angiotensin (Ang) II receptor antagonist, SC-52458, on peak and plateau components of Ang II-induced contraction were evaluated in the guinea-pig taenia coli. 2. 2. SC-52458 suppressed both the components of and increases in cytoplasmic Ca 2+ concentrations, [Ca 2+] i, coupled with the contraction by Ang II; tetrodotoxin and atropine did not affect the contractions. 3. 3. SC-52458 inhibited a plateau component of the contraction induced by K +-depolarization to some extent, without affecting a peak component. 4. 4. SC-52458 suppressed both the contraction and increase of [Ca 2+] i by antagonizing AT 1 receptors in the smooth muscle.
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