Abstract
Saikosaponins a and d inhibited adrenaline-induced lipolysis in fat cells isolated from epididymal adipose tissue of rats. Saikosaponins a, b1, b2, b4, c and d inhibited ACTH-induced lipolysis in the fat cells. Insulin-stimulated lipogenesis in adipose tissue was significantly reduced by saikosaponin d. Propranolol (a β-blocker) inhibited not only lipolytic actions induced by adrenaline and ACTH but also lipogenesis stimulated by insulin. In contrast to propranolol, saikosaponins b1, b2, b4 and c selectively inhibited ACTH-induced lipolysis without affecting the lipogenetic effect of insulin. The structure-activity relationship of saikosaponins is discussed.
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