Abstract
AbstractInhibitory effects of saffron extract, a commonly used food spice, were studied against subcutane-ously inoculated solid Dalton's lymphoma ascites (DLA), Ehrlich ascites carcinoma (EAC) and Sarcoma-180 (S-180) tumours in mice. Oral administration of 100 mg/kg of the saffron extract significantly inhibited the growth of DLA and S-180 solid tumour by 87 and 41%, respectively. A dose of 150 mg/kg delayed the onset of tumour formation and inhibited further growth of a delayed Dalton's lymphoma ascites solid tumour by 80%. Chromium release cytotoxicity assay reflected the sensitivity of DLA and S-180 tumour cells to cytolysis (in vitro) in the presence of the extract. Estimation of serum vitamin A and β-carotene levels from S-180 tumour bearing mice treated with saffron extract indicated elevated serum levels of serum vitamin A and β-carotene. Chemical analysis of the antitumour compound from saffron extract indicated that crocin (a natural carotenoid) was responsible for the observed biological effect...
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