Abstract
Objective To investigate the inhibitory effects of safflower polysaccharide （SPS） on tumor growth and metastasis of T739 mice transplanted with Lewis lung carcinoma cells, then explore the anti-tumor mechanism of action. Methods The xenografts derived from Lewis lung carcinoma cells were established in T739 mice. Inoculated mice were randomly divided into control group, low dose SPS group, moderate dose SPS group and high dose SPS group, daily oral administration, a total of 28 times. Tumor volume and weight were measured and lung metastatic foci of the mice were observed under microscope. MTF assay was used to investigate both the inhibitive effect of SPS on Lewis lung carcinoma cells and the influence on proliferation of T lymphocytes. Results There was no inhibitory effect of SPS on Lewis lung carcinoma cells in vitro. In vivo, SPS could promote proliferation of T lymphocytes and inhibit tumor growth and metastasis. There were significant differences when comparing the SPS groups with control group in terms of the volume, weight and lung metastatic foci of the transplanted tumor （P 〈 0.05 ）. Conclusion SPS could inhibit the tumor growth and metastasis. The anti-tumormechanism of action was about related to increase the immunological function of mice. Key words: Safflower Polysaccharide; Lewis lung carcinoma; Transplanted tumor; Lung metastatic
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