Abstract
Selected hematology and serum biochemistry usually used as prognostic indicators of disease were monitored in rabbits parasitized by Sarcoptes scabiei (L.) var. canis during and after treatment, in parallel with food consumption, body weight, and clinical manifestation of the disease. Experimental rabbits were infested with S. scabiei , the infestation was allowed to develop in intensity for 42 wk, the rabbits were treated with ivermectin, and then monitored for another 20 wk recovery period after treatment. Infested rabbits grew at the same rate as control rabbits during weeks 1–17 after initial infestation, then they lost weight during weeks 18–42 as the infestation became severe. Severely infested rabbits developed anemia, which was evident by reduced hemoglobin, hematocrit, and mean corpuscular hemoglobin. Serum iron concentration of infested rabbits in comparison with control rabbits was lower but not statistically different. Severely infested rabbits exhibited significantly reduced total white blood cell, lymphocyte, and eosinophil counts. Mean serum gamma glutamyltransferase, serum glutamic pyruvic transaminase, albumin, albumin/globulin ratio, blood urea nitrogen (BUN), creatinine, and calcium levels were reduced, and total serum protein, triglycerides, globulins, and chloride were elevated in severely infested rabbits. Severely infested rabbits compared with controls showed no significant differences in average values for serum phosphorus, sodium, potassium, lactic acid dehydrogenase (LDH), serum glutamic oxaloacetic transaminase (SGOT), total bilirubin, alkaline phosphatase (ALP), cholesterol, BUN/creatinine ratio, uric acid, glucose, and iron. However, some individual rabbits showed marked changes in LDH, ALP, SGOT, cholesterol, glucose, and BUN/creatinine ratio, which indicates that not all parasitized rabbits were affected in the same way. All abnormal conditions in the infested rabbits returned to normal following treatment for scabies.
Published Version
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