Abstract
The bacteriostatic mechanism of resveratrol (RES) on Acetobacter sp. based on the cell membrane, intracellular enzymes and DNA was studied. Our results showed that the minimum inhibition concentration (MIC) of RES was 2 mg/mL, and the growth curve confirmed its better bacteriostatic activity against Acetobacter sp. The content of unsaturated fatty acids (UFAs) and hydroxyl fatty acids (HFAs) of Acetobacter sp. cell membrane after low-concentration RES treatment increased, while the content of saturated fatty acids (SFAs) and cyclic fatty acids (CFAs) decreased. Furthermore, the cell membrane fatty acid-related genes (fabA, fabG, and cfa) and stress-regulating gene (rpoH) were down-regulated. Moreover, RES not only disrupted the cell morphology and the cell membrane integrity of Acetobacter sp., but also caused oxidative damage to the cell membrane of Acetobacter sp. In addition, RES reduced the activity of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), and could bind genomic DNA through a groove pattern, which revealed the inhibitory mechanism of RES against Acetobacter sp. at the molecular level.
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