Effects of restricted fluid resuscitation on reticuloendothelial system in rats with hemorrhagic shock

Abstract

Objective To investigate the effects of restricted fluid resuscitation on reticuloendothelial system in rats with hemorrhagic shock. Methods A model of rat with severe hemorrhagic shock caused by active bleeding was established in 60 SD rats. Those rats were randomly divided into control group, NF group(no fluid resuscitation group), NS40 group(restricted fluid resuscitation group) and NS80 group(conventional large_volume fluid resuscitation group), After different treatments, survival rats in each group were detected and compared ofthe phagocytosis function of the Kupffer cell and the peritoneal macrophage. Results Restricted fluid resuscitation could reduce the mortality rate of rat in shock stage significantly(P<0.05). When compared with NS40 and NS80 group, phagocytosis function of the Kupffer cell and the peritoneal macrophage in NS40 group rats was obviously increased(P<0.05). Conclusion Restricted fluid resuscitation can significantly improve the phagocytic function of the Kupffer cell and the peritoneal macrophage in hemorrhagic shock rat, enhance the immune function of rat to reduce the mortality. Key words: Restricted fluid resuscitation; Hemorrhagic shock; Reticuloendothelial system