Abstract
Evidence of the role of ANGPTL3, a liver-secreted glycoprotein, in serum lipid turnover, led us to hypothesize that this protein may be involved in modification of the lipid profile induced by exercise-training. Given the lack of data regarding this issue, the main goal of the present study was to investigate the effects of regular participation in a recreational physical activity program on serum ANGPTL3 and selected lipid profile measures in young, apparently healthy female and male adults. We compared serum ANGPTL3, lipid profile measures, common lipid ratios, the Atherogenic Index of Plasma (AIP) and glucose in fasting blood samples derived from 22 active physical education students including active females (AF, N=6) and males (AM, N=16) with samples from 28 relatively sedentary age-matched peers, including female (SF, N=9) and male (SM, N=19) individuals not involved in any regular physical conditioning program. Despite high inter-individual variability of serum ANGPTL3, there was a general tendency toward higher serum ANGPTL3 and HDL-C in women compared to men, but without significant differences related to their physical activity status. Based on both routine lipid profile measures and lipid ratios, all participants had normal lipid profiles, normal glycemia, as well as favorable anthropometric indices not suggesting increased cardiometabolic risk. However, lower levels of the TG/HDL-C ratio and AIP in physically active compared to relatively sedentary participants, reflecting the predominance of large, buoyant LDL particles, strongly support the view of beneficial health-promoting effects of regular participation in recreational sport activities.
Highlights
An abnormal blood lipid profile, characterized by elevated levels of total cholesterol, low density lipoprotein-cholesterol (LDL-C) and triacylglycerols (TG), and a low level of high-density lipoprotein-cholesterol (HDL-C), is recognized as one of the major risk factors for coronary heart disease (CHD) (Ingelsson et al, 2007) and a stroke (Go et al, 2014)
The primary aim of the present investigation was to examine whether the participation in a recreational physical activity program would affect serum angiopoietin like protein 3 (ANGPTL3) and the lipid profile in young healthy adults
Our pilot study, focused on the evaluation of differences in serum ANGPTL3 level between healthy, physically active subjects and their relatively sedentary counterparts, http://www.johk.pl revealed that despite high inter-individual variability of this liver-derived secretory factor, there was a general tendency toward higher serum ANGPTL3 in women compared to men (p
Summary
An abnormal blood lipid profile, characterized by elevated levels of total cholesterol, low density lipoprotein-cholesterol (LDL-C) and triacylglycerols (TG), and a low level of high-density lipoprotein-cholesterol (HDL-C), is recognized as one of the major risk factors for coronary heart disease (CHD) (Ingelsson et al, 2007) and a stroke (Go et al, 2014). It is well established that regular physical activity induces metabolic adaptations characterized by improvement of the blood lipid profile and reduced CHD risk (Durstine et al, 2001). The magnitude of these beneficial changes in the lipid profile, typically recorded in endurance athletes, is related to both intensity and duration of exercise (Durstine et al, 2001). 3 - Department of Physiotherapy in Neurological and Musculoskeletal Disorders, The Jerzy Kukuczka Academy of Physical Education in Katowice. Authors submitted their contribution to the article to the editorial board. Accepted for printing in the Journal of Human Kinetics vol 49/2015 in December 2015
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