Effects of recent circadian rhythms on sedative and cardiovascular effects of dexmedetomidine

Abstract

Objective To investigate the effects of recent circadian rhythms on the sedative and cardiovascular effects of dexmedetomidine. Methods The clinical data of 64 patients who underwent surgical treatment of lower abdomen and lower extremity from Shouguang People’s Hospital from July 2016 to February 2017 were analyzed. The enrolled patients aged 18 to 65 years, 33 patients of which received anesthesia from 7∶00 to 11∶00 in the morning as group A, and 31 patients who received anesthesia from 13∶00 to 17∶00 in the afternoon were group B. The change rate of heart rate (HR) and pulse oxygen saturation (SpO2), bispectral index (BIS) value of the two groups were analyzed. Results After intravenous injection of 1 μg/kg dexmedetomidine, the change rates of HR and SpO2 in group A were not significantly different from those in group B at any time points (P>0.05). The BIS values of group A at T3 to T6 were 85.7±6.3, 83.2±3.9, 77.9±5.9, 72.9±5.8, respectively. There was a statistically significant difference in the BIS value between the two groups at the same point(P<0.05). Conclusions The recent circaclian rhythms can affect the sedative effects of dexmedetomidine, but has no significant effect on the cardiovascular effects of dexmedetomidine. Key words: Dexmedetomidine; Recent Circadian rhythms; Bispectral index; Cardiovascular effect