The sedative effect of dexmedetomidine and the hemodynamic influence of dexmedetomidine on tracheal intubation

Abstract

Objective To study the influence of dexmedetomidine (Dex) on auditory evoked potential index (AAI) and its hemodynamic influence as tracheal intubation. Methods 60 patients were randomized divided into dexmedetomidine group (D group) or control group(C group).Patients were intravenously pumped into Dex 1 μg/kg with in 20 min in D group,the same volume placebo was administered in C group.Tracheal intubation was done 2 min after medication.Systolic blood pressure (SBP),mean arterial pressure(MAP),diastolic blood pressure(DBP),heart rates(HR),pulse oxygen saturation(SpO2) and AAI were recorded at the following time points (before medication,before induction,before intubation,the time after intubation,3 min after intubation,5 min after intubation and 10 min after intubation). Results Before medication,the general conditions have no difference in two groups.The values of AAI before medication and before induction were (62±5) and (35±6)(P＜0.05) respectively,decreased by 53％,and there were no difference in C group.The SBP,MAP,DBP and HR at the time after intubation in D group were (112±18),(90±19),(80±19) mm Hg(1 mmHg=0.133 kPa) and (81±14) beat/min respectively,while in C group were (140±21),(109±16),(97±17) mm Hg,(95±10) beat/min respectively,there were significant difference between the two groups(P＜0.05). Conclusions Dex has good sedative effects before surgery,and it can also depress the stress responses of tracheal intubation effectively. Key words: Dexmedetomidine; Tracheal intubation; Hemodynamics; Auditory evoked potential index