Abstract
Whole-cell/voltage-clamp recordings were made from dissociated bullfrog sympathetic neurons to examine the sensitivity of potassium currents to a potassium channel blocker quinine (1–500 μM). Among three currents tested, a rapidly inactivating A-type current (IA) was the most sensitive to the block by quinine (IC50≈22 μM). A non-inactivating M-type current (IM) was the least sensitive (IC50≈445 μM), and the sensitivity of a slowly inactivating delayed rectifier-type current (IK) was in between (IC50≈115 μM). Results suggest that the ability of quinine to block different types of potassium currents such as IA and IM with significantly different IC50 values would be of help for the potassium channel pharmacology in amphibian autonomic ganglion cells.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
