Abstract
Arachidonic acid (AA) and its metabolites are the possible second messengers for channel modulations in many cells. AA may modulate ion conductance, either directly (Ordway et al. 1991), or indirectly through lipoxygenase metabolites (Piomelli and Greengard 1990). In hippocampal neurons, AA or its metabolite mediates the somatostatin-induced augmentation of the M-current (Schweitzer et al. 1990). AA reduced nicotine-induced responses in chick ciliary ganglion neurons (Vijayaraghavan et al. 1995). In bullfrog sympathetic neurons, AA increases M-current (Yu 1995), while it reduces the nicotinic receptor-mediated responses (Minota and Watanabe 1997). However, the effects of AA on muscarinic receptor-mediated responses have not been studied in detail. I report here the action of AA on cholinergic synaptic transmission in bullfrog (Rana catesbeiana) sympathetic neurons. Single-electrode current- or voltage-clamp recordings were made from B-type neurons.
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