Abstract
This study is aimed at exploring the effect of pulmonary surfactant (PS) combined with noninvasive positive pressure ventilation on the levels of Keratin-14 (KRT-14) and Endothelin-1 (ET-1) in peripheral blood and the therapeutic effect of neonatal respiratory distress syndrome (NRDS). Altogether 137 cases of neonates with respiratory distress syndrome treated in our hospital from April 2016 to July 2018 were collected. Among them, 64 cases treated with noninvasive positive pressure ventilation were considered as the control group, and 73 cases treated with PS combined with noninvasive positive pressure ventilation were considered as the observation group. The expression of KRT-14 and ET-1 in the two groups was compared. The therapeutic effect, death, complications, and blood gas indexes PaO2, PaCO2, and PaO2/FiO2 in the two groups were compared. Receiver operating characteristic curve (ROC) was applied to analyze the diagnostic value of KRT-14 and ET-1 in the therapeutic effect of NRDS. The effective rate of the observation group was higher than that of the control group. After treatment, PaO2 and PaO2/FiO2 in both groups were notably higher than that before treatment, while PaCO2 was notably lower than that before treatment. And after treatment, the levels of PaO2 and PaO2/FiO2 in the observation group were remarkably higher than that in the control group; PaCO2 was notably lower than that in the control group. After treatment, the levels of KRT-14 and ET-1 in the two groups were remarkably lower than those before treatment, and the levels of KRT-14 and ET-1 in the observation group were considerably lower than those in the control group after treatment. ROC curve showed that the area under the curve (AUC) of KRT-14 was 0.791, and the AUC of ET-1 was 0.816. PS combined with noninvasive positive pressure ventilation can notably improve the therapeutic effect of NRDS. KRT-14 and ET-1 levels may be potential therapeutic diagnostic indicators.
Highlights
Neonatal respiratory distress syndrome (NRDS) is one of the most common diseases in neonatal intensive care unit, the incidence rate of which is about 7% among infants, and it is one of the main causes of neonatal death in hospital in China [1, 2]
The other 73 infants received treatment of pulmonary surfactant (PS) combined with noninvasive positive pressure ventilation on the basis of basic treatment were considered as the observation group, including 38 males and 35 females
All neonates were diagnosed as NRDS by imaging, and the diagnostic criteria were based on the European consensus guidelines on the management of respiratory distress syndrome-2016 update [16]
Summary
Neonatal respiratory distress syndrome (NRDS) is one of the most common diseases in neonatal intensive care unit, the incidence rate of which is about 7% among infants, and it is one of the main causes of neonatal death in hospital in China [1, 2]. The main mechanism of the disease is hypoxemia and hypercapnia caused by lack of surfactant. Invasive ventilation is easy to cause a series of complications such as lung infection, ventilator-associated lung injury, etc., BioMed Research International which makes people pay wide attention to the clinical application of noninvasive ventilation [7]. It has been found in lots of studies that noninvasive positive pressure ventilation can significantly improve the condition of NRDS neonates and has good safety [8, 9]. Some studies reveal that PS combined with noninvasive positive pressure ventilation can further improve the clinical efficacy [10]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
