Abstract
The effect of a single intraperitoneal dose of the antidepressive drugs, Imipramine and Prothiadene, was studied on the level of free nucleotides in the rat brain. Imipramine and Prothiadene have no marked influence on the levels of adenine nucleotides after 1 hr but after 3 hr action they increase ATP levels, and lower ADP; Prothiadene also lowers the level of AMP. Hence the molar ratios ATP to AMP and ATP to ADP rise significantly. Both drugs elevated UTP levels in rat brain 1 hr after administration, and this level remained high also after action of these substances for 3 hr.
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