Abstract
Cyclic AMP levels were estimated in brains of mice and rats which had been injected with prostaglandins intravenously. The animals were killed, and tissue fixation was also achieved, by microwave radiation. PGE 2 caused a 72% increase in the cyclic AMP content of whole brains of mice. PGE 1 led to a 57% increase, whereas PGF 2α was less effective but still raised cyclic AMP levels significantly. The most effective dose was 1 mg/kg, and caused the maximal increase within 1 min of injection. Cyclic AMP levels had declined almost to control levels within 2 min after injection. The estimation of cyclic AMP levels in 7 discrete regions of rat brains showed that the increase of the cyclic nucleotide in response to PGE 2 (1 mg/kg i.v.) was highest in the cerebral cortex, intermediate in the thalamus, and lowest in the cerebellum and brain stem. These results suggest that central effects of prostaglandins are mediated by an increase of cyclic AMP levels in brain.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
