Abstract
Rats receiving 100 ppm, p,p′-DDT in their drinking water for a period of 45 days show reduced basophilia of the centrilobular liver cells. The basophilic fragments are scattered throughout the cytoplasm in most of these cells. The animals receiving 100 ppm PTU in their drinking water show similar morphological changes. The animals receiving p,p′-DDT plus PTU exhibit advanced changes involving almost all the cells of the inner two-thirds of the hepatic lobule. The ergastoplasm is reduced to a few small fragments located near the cell membrane. The remainder of the cytoplasm is very clear and foamy in appearance. It is considered that the changes in the liver induced by p,p′-DDT are potentiated by the effect of PTU on the hypophyso-thyroid system. This view is supported by our previous findings in the liver of surgically thyroidectomized p,p′DDT-receiving rats.
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