Abstract
ABSTRACTPurpose:To investigate the effects of propofol on inflammatory response and activation of p38 mitogen-activated protein kinase (MAPK) signaling pathway in rats with ventilator-associated lung injury (VALI).Methods:Thirty-six Sprague Dawley (SD) rats were divided into control, VALI and VALI+propofol groups. The VALI group received the mechanical ventilation for 2 h. The VALI+propofol group received the mechanical ventilation for 2 h, which was accompanied by intravenous injection of propofol with dose of 8 mg·kg-1·h-1. At the end, the mean arterial pressure (MAP) and blood gas indexes were measured, and the lung wet/dry mass ratio (W/D) and biochemical indexes of lung tissue and bronchoalveolar lavage fluid (BALF) were determined.Results:Compared with VALI group, in VALI+propofol group the blood pH, partial pressure of oxygen, partial pressure of carbon dioxide and MAP were increased, the lung W/D, lung tissue myeloperoxidase activity and total protein concentration, white blood cell count, and tumor necrosis factor α, interleukin 1β and interleukin 6 levels in BALF were decreased, and the p-p38 MAPK protein expression level and phosphorylated p38 MAPK (p-p38 MAPK)/p38 MAPK ratio were decreased.Conclusions:Propofol treatment may alleviate the VALI in rats by reducing the inflammatory response and inhibiting the activation of p38 MAPK signaling pathway.
Highlights
In recent years, the clinical application of ventilator is increasing, but the lung injury caused by improper use of ventilator or its long application time has gradually attracted the attention of clinicians[1]
Results of this study showed that, at the end of mechanical ventilation, there was no significant difference of p38 mitogen-activated protein kinase (MAPK) protein expression level in lung tissue among the three groups
The propofol treatment can alleviate the ventilator-associated lung injury (VALI) in rats
Summary
The clinical application of ventilator is increasing, but the lung injury caused by improper use of ventilator or its long application time has gradually attracted the attention of clinicians[1]. If the ventilatorassociated lung injury (VALI) cannot be treated in time, it will seriously endanger the respiratory function of patients, and even lead to death. VALI is mainly treated by carbon dioxide inhalation, anti-inflammatory treatment, adrenoceptor drug therapy and renin-angiotensin-aldosterone system drug therapy, but there is no drug to improve the prognosis of VALI. Propofol is a commonly used drug for sedation during mechanical ventilation It has anti-inflammatory properties, can reduce the lung injury and improve the oxygenation during mechanical ventilation, but the mechanism is unclear[8,9]
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