Effects of propofol and midazolam on the prognosis of patients treated with noninvasive positive pressure ventilation

Abstract

Objective To compare the effects of propofol and midazolam on the prognosis of patients treated with noninvasive positive pressure ventilation. Methods A prospective, single-blind, randomized controlled trial(RCT) was conducted in 90 patients who were treated with noninvasive ventilation for acute dyspnea in the ICU of the Sixth People′s Hospital Affiliated to Shanghai Jiaotong University from October 2014 to December 2016.They were randomly divided into three groups according to the digital table, with 30 cases in each group.The control group was not given sedation treatment.The propofol group was given propofol 0.5~1 mg/kg, and then administered by intravenous infusion of 1 mg·kg-1·h-1 with a micropump.The midazolam group was given midazolam 0.05-0.1mg/kg, and then with intravenous infusion of 0.05-0.1 mg·kg-1·h-1 maintaining the patients' sedation goals(Ramsay score of 2). The vital signs and blood gas analysis indicators were recorded.The incidence of tracheal intubation, the incidence of hospital infection, length of ICU and hospital stay, mortality and sedation-related complications were compared. Results The tracheal intubation rate in the propofol group was similar to that in the midazolam group(20.0% vs.23.3%, χ2=2.65, P>0.05), while the tracheal intubation rate(46.7%) in the control group was significantly higher(χ2=4.21, 4.17, all P 0.05). The incidence rates of hospital infection in the propofol group and midazolam group were 6.6%(2 cases) and 10.0%(3 cases), which were significantly lower than 33.3%(10 cases) in the control group (χ2=4.32, 4.23, all P<0.05). Conclusion The use of mild sedation in patients of acute dyspnea treated with noninvasive positive pressure ventilation can improve the patients' tolerance rate, reduce the rate of tracheal intubation and the incidence of hospital infection, and decrease the length of ICU and hospital stay, without significant adverse reactions.There was no significant difference between propofol and midazolam. Key words: Propofol; Midazolam; Sedation; Continuous positive airway pressure; Respiration, artificial; Dyspnea; Cross infection; Prognosis; Comparative effectiveness research