Abstract
Eleven fresh ex vivo porcine kidneys were perfused in the artery, vein and ureter with degassed Dulbecco׳s Modified Eagle Medium (DMEM).The effect of perfusion pressure was evaluated using ten different pressures combinations. The shear modulus of the tissues was estimated during perfusion using shear wave elastography. The organ weight change was measured by a digital scale and cameras were used to follow the changes of the dimensions after each pressure combination.The effect of perfusion on the weight and the thickness was non-reversible, whereas the effect on the shear modulus was reversible. Pressure was found to increase the average shear modulus in the cortex by as much as 73%. A pressure of 80mmHg was needed to observe tissues shear modulus in the same range as in vivo tests (Gcortex=9.1kPa, Gmedulla=8.5kPa ex vivo versus Gcortex=9.1kPa, Gmedulla=8.7kPa in vivo in Gennisson et al., 2012).
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