Abstract
In this study, a porous synthetic hydroxyapatite was microcoated with three different thicknesses of PLA and compared to uncoated samples in an in vivo model to determine the effect of coating on bone ingrowth. Coatings were mixtures of chloroform and DL-polylactic acid in ratios of 3:1, 10:1, and 30:1. These coated specimens, along with uncoated specimens, were implanted transcortically into the tibiae of New Zealand White rabbits. At 12 weeks the specimens with 3:1 and 10:1 coatings seemed to inhibit bone ingrowth as measured from interface shear tests (p<.025), and to a lesser degree so did 30:1. However, at 24 weeks, possibly due to degradation of the coating, interface shear strength in specimens with all coating thicknesses was not statistically different from the shear strength in uncoated specimens.
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