Effects of Physical Activity on the Performance of 24-h Urinary Sucrose and Fructose as a Biomarker of Total Sugars Intake (P18-128-19)

Abstract

ObjectivesUrinary sucrose and fructose has been suggested as a predictive biomarker of total sugars intake based on research involving UK adults. The purpose of this study was to determine the association between sugars consumption and 24-hour urinary sucrose and fructose (24uSF) in US adult population and to investigate the effect of physical activity on this association. MethodsFifty seven free-living healthy subjects 20 to 68 years old, participated in a 15-day highly controlled feeding study, consuming their habitual diet, provided by the research metabolic kitchen. Dietary sugars were estimated using Nutrition Data System for Research (NDSR). Subjects collected eight 24-hour urine samples measured for urinary sucrose and fructose. Physical activity was assessed daily using a validated 15-day log that inquired about 38 physical activities across six domains; home activities, transportation, occupation, conditioning, sports and leisure. ResultsThe 15-d mean total sugars and added sugars intake (SD) of the study population was 112.2 (33.1) g/day and 65.8 (29.0) g/day (9.7%EI), respectively. Significant moderate positive correlation was found between 15-d mean total sugars intake and 8-day mean 24uSF (r = 0.56, P < 0.001). Similarly, added sugars were moderately correlated with 24uSF (r = 0.56, P < 0.001), while no correlation was found between naturally-occurring sugars and 24uSF (r = 0.070, P < 0.001). In a linear multiple regression, total and added sugars each explained 30% of variability in 24uSF (Adjusted R2, p value; total sugars: 0.297, 0.001; added sugars: 0.301, P < 0.001). We found no effect of physical activity on the association between dietary and urinary sugars in neither the correlation nor the linear regression analysis. Conclusions24uSF showed moderate association with both total and added sugars consumption in US adults. No evidence was found showing that physical activity levels affect the association between 24uSF and sugars intake in US adults. Funding SourcesNational Cancer Institute.