Abstract
The aldehyde dehydrogenases and the drug‐metabolizing system (the mixed function oxidase) were studied in Wistar rats treated with ethanol and phenobarbital. Phenobarbital treatment had no effect on the microsomal aldehyde dehydrogenase activity, whereas the mitochondrial aldehyde dehydro‐genase activity was slightly decreased and the activities of ethylmorphine demethylase, NADPH‐cytochrome c reductase and the concentration of cytochrome P‐450 were increased two to threefold. Ethanol treatment caused no changes in the activities of the aldehyde dehydrogenases, and the drug metabolizing system was only slightly affected. Very little aldehyde dehydrogenase activity was found in the cytosol from livers of either control, ethanol‐treated or phenobarbital‐treated rats. The results are discussed with particular reference to the oxidation of acetaldehyde and other aldehydes during ethanol metabolism.
Published Version
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