Abstract
Abstract : Neuropathic pain is a common contributor to chronic pain syndromes in wounded warriors . We seek to answer whether the direct application of pregabalin to an injured nerve would relieve neuropathic pain. Forty male Sprague Dawley rats were randomized into four study groups: Sciatic nerve crush injury with perineural pregabalin infusion (T), sciatic crush injury with perineural saline infusion (SA), nerve crush injury with subcutaneous pregabalin (SC), and a sham group without nerve injury (C). Group T had significantly better pain behavior scores than both Group SC and Group SA. Pregabalin does not appear to have neurotoxic effects. Perineural pregabalin treatment is superior to systemic pregabalin in reducing pain behavior in a sciatic nerve crush injury model demonstrating that the drug likely has a peripheral mechanism of action in addition to central mechanisms. Perineural application of pregabalin to an injured nerve may be promising as a novel approach for the treatment of neuropathic pain.
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