Effects of paroksetine administration on cortical EEG of elderly rats

Abstract

Event Abstract Back to Event Effects of paroksetine administration on cortical EEG of elderly rats Bilge Özerman1*, A. Nurten2, U. Dalanay3, I. Özen2, S. Karamürsel4 and I. Kara2 1 Department of Biophysics, Istanbul Medical Faculty, Istanbul University, Turkey 2 Department of Neuroscience, Institute for Experimental Medical Research, Istanbul University, Turkey 3 Berlin Medical University, Charite, Germany 4 Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Turkey Paroxetine, which is a selective serotonin reuptake inhibitor (SSRI), was used for treatment of depression. We aimed to study the effect of paroxetine on cortical electrical activity of elderly rats, as the age-related serotonin reduction occurs in cerebral cortex. Elderly Wistar albino rats (n=9) were anaesthetized with thiopental (50 mg/kg i.p.). Eight pairs of epidural electrodes were positioned symmetrically on both hemispheres to the medial and frontal localization of pre- and post- frontoparietal and occipital regions. A reference electrode was placed above the cerebellum. The following week of the operation control EEG recordings carried out by Neuroscan during 15 min for each animal. Records were repeated at the end of three weeks of paroxetine (4 mg/kg i.p.) administration. Subsequent continuous EEG recordings were compared as frequency spectra with the basal EEG value of the animal. EEG records were divided into 2 seconds epochs and analyzed by averaged frequency spectra (0-48 Hz). Moving averages were calculated for five points. A series of point to point two tail paired Student's t-test was applied for the each channel. Topographic maps of rats were constructed from the grand average of amplitude spectra. The frequency band of 0.5- 4 Hz was expressed as delta, 4-8 Hz as theta, 8-11 Hz as alpha1, 11-14 Hz as alpha2, 14-25 Hz as beta1, 25-35 Hz as beta2 and 35-45 Hz as gamma. Following three weeks of paroxetine administration, the amplitudes of delta, alpha2, beta1 and gamma bands were significantly altered (p<0.05). The increment in the amplitude was determined for delta frequency band of medial cortical localizations in both hemispheres and for gamma frequency band of medial postfrontal and lateral frontal cortex in right hemisphere with localizations excluded frontal and medial postfrontal cortex in left hemisphere. The decrement in the amplitude of alpha2 and beta1 bands was identified in all cortical localizations. The frequency analysis of continuous EEG recordings from 16 channels of elderly Wistar rats was showed that paroxetine administration of three weeks caused significant alterations in cortical activity. These findings guided this study for the next step to carry on with the analysis of evoked potentials in order to elucidate the cognitive effect of paroxetine administration. Conference: 10th International Conference on Cognitive Neuroscience, Bodrum, Turkey, 1 Sep - 5 Sep, 2008. Presentation Type: Poster Presentation Topic: Animal Models of Cognition Citation: Özerman B, Nurten A, Dalanay U, Özen I, Karamürsel S and Kara I (2008). Effects of paroksetine administration on cortical EEG of elderly rats. Conference Abstract: 10th International Conference on Cognitive Neuroscience. doi: 10.3389/conf.neuro.09.2009.01.079 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 01 Dec 2008; Published Online: 01 Dec 2008. * Correspondence: Bilge Özerman, Department of Biophysics, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey, bilgeozerman@hotmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Bilge Özerman A. Nurten U. Dalanay I. Özen S. Karamürsel I. Kara Google Bilge Özerman A. Nurten U. Dalanay I. Özen S. Karamürsel I. Kara Google Scholar Bilge Özerman A. Nurten U. Dalanay I. Özen S. Karamürsel I. Kara PubMed Bilge Özerman A. Nurten U. Dalanay I. Özen S. Karamürsel I. Kara Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.