P50 gating at acute and post-acute phases of schizophrenia

Abstract

Event Abstract Back to Event P50 gating at acute and post-acute phases of schizophrenia Alp Üçok1*, Müge Devrim-Üçok2 and H. Keskin-Ergen2 1 University of Istanbul, Istanbul Medical Faculty, Department of Psychiatry, Turkey 2 University of Istanbul, Istanbul Medical Faculty, Department of Physiology, Turkey Deficit in P50 sensory gating has repeatedly been shown in schizophrenia. In order to determine the contribution of trait and/or state features to P50 gating deficit in schizophrenia we evaluated the P50 gating in patients with first-episode schizophrenia (FES) at acute and post-acute phases. Paired clicks (S1 and S2) were presented 500 ms apart. P50 gating was quantified both by S2/S1 ratio (P50 amplitude to S2 divided by the P50 amplitude to S1) and S1-S2 difference (difference between the P50 amplitude to S1 and S2). Subject groups comprised 16 patients with FES and 24 age-, gender- and education-matched healthy controls. Patients were tested at the acute phase of the illness and retested at the post-acute phase when their positive symptoms improved. Mean inter-test interval was 2.65+/-2.42 months. Patients were on atypical antipsychotic treatment (risperidone, olanzapine or quetiapine) at the post-acute phase. P50 gating was impaired in patients at the acute phase compared to controls (S2/S1 ratio, p=0.024; S1-S2 difference, p=0.05). However, at the post-acute phase P50 gating was increased compared to the acute phase (S2/S1 ratio, p=0.021; S1-S2 difference, p=0.04), reaching to the gating values of controls. No correlation was found between P50 gating and clinical severity measures. P50 gating improvement might be emerged from atypical antipsychotic medication. However, there is little evidence in the extant literature that other than the clozapine atypical antipsychotics exert a restorative effect on sensory gating. This controversy could be explained by the fact that previous studies evaluated chronic or recent-onset schizophrenia patients; however, all patients had a FES in our study. Randomized studies which include placebo and different antipsychotics in a large sample are needed to determine the effects of individual atypical antipsychotics on P50 gating in first-episode patients. Conference: 10th International Conference on Cognitive Neuroscience, Bodrum, Turkey, 1 Sep - 5 Sep, 2008. Presentation Type: Poster Presentation Topic: Neuropsychiatric Disorders Citation: Üçok A, Devrim-Üçok M and Keskin-Ergen H (2008). P50 gating at acute and post-acute phases of schizophrenia. Conference Abstract: 10th International Conference on Cognitive Neuroscience. doi: 10.3389/conf.neuro.09.2009.01.378 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 16 Dec 2008; Published Online: 16 Dec 2008. * Correspondence: Alp Üçok, University of Istanbul, Istanbul Medical Faculty, Department of Psychiatry, Istanbul, Turkey, alpucok@superonline.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Alp Üçok Müge Devrim-Üçok H. Keskin-Ergen Google Alp Üçok Müge Devrim-Üçok H. Keskin-Ergen Google Scholar Alp Üçok Müge Devrim-Üçok H. Keskin-Ergen PubMed Alp Üçok Müge Devrim-Üçok H. Keskin-Ergen Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.