Effects of parecoxib of bone mineral density and osteocalcin of rats and intervention of ketamine

Abstract

Objective To study the effects of parecoxib on bone metabolism of rats at different time points,and intervention of ketamine.Methods Thirty-two SD rats were randomly divided into four groups:control group,ketamine group,parecoxib group,ketamine + parecoxib group.The treatments were given once every 12 h for three days.After being finished doses for seven days,fourteen days and thirty-five days,bone mineral density (BMD) & osteocalcin (BGP) measurements would be separately taken.Results Result of seven-day BMD measurement:It was not statistically significant between the different groups (F =I.802,P ＞ 0.05).Result of fourteen-day BMD measurement:It was not statistically significant between the different groups (F =2.699,P ＞ 0.05).Result of thirty-five-day BMD measurement:Each of them were 0.1444 ±0.0036,0.1426 ± 0.0024,0.1377 ± 0.0005 and 0.1308 ± 0.0066,It was showed statistically significant between the different groups (F =15.258,P ＜ 0.05).By comparison,It was showed statistically significant between the different of precoxib group and others;It was showed statistically significant between the different of ketamine group and others,too;Meanwhile,It was not statistically significant between control group and ketamine group.Result of seven-day BGP measurement:Each of them were 222.500 ± 9.607,229.830 ±6.795,226.830 ± 12.828 and 115.830 ± 11.125,It was showed statistically significant between the different of ketamine group and others (F =172.335,P ＜ 0.05).Result of fourteen-day BGP measurement:Each of them were 229.830 ±5.193,221.670 ± 16.884,85.500 ± 15.592 and 223.670 ±34.256,It was showed statistically significant between the different of precoxib group and others (F =67.768,P ＜0.05).Result of thirty-five-day BGP measurement:Each of them were 231.170 ± 72.486,221.000 ±51.166,100.500 ± 14.053 and 101.500 ± 8.643,It was showed statistically significant between the different precoxib group& ketamine group and control group & ketamine group (F =15.420,P ＜0.05).Conclusion The use of parecoxib weakened BMD and BGP,and had an adverse impact on symphysis.The process may be accelerated after using ketamine. Key words: Parecoxib; Bone mineral density; Bone gla protein; Ketamine