Abstract
Summary1) The effect of various compounds upon release of lactogenic hormone from the hypophysis in response to nursing stimuli has been studied in 14-day postpartum lactating rats. 2) Atropine, Dibenamine and Nembutal effectively blocked pituitary lactogen discharge since 30 minutes nursing evoked no decline (2.35, 2.39 and 2.46 Reece-Turner units/100 g, respectively) from previously obtained control prenursing level (2.44 R-T units/100 g). The normal level following 30 minutes nursing was previously determined as 1.66 R-T units/100 g. Since Dibenamine is a potent adrenergic blocking agent and atropine a cholinergic blocking agent, it is suggested cholinergic and adrenergic links are involved in the reflex arc responsible for lactogen discharge from rat pituitary gland. 3) Oxytocin injected i.v. into Nembutal-anaesthetized lactating rats in physiological doses failed to alter pituitary lactogen (2.49 R-T units/100 g) from the control prenursing level. Amounts of oxytocin 30 and 60 x this dose produced bu...
Published Version
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