Abstract
ABSTRACTα‐Keratins from horny cells of lesional and non‐lesional skin in psoriatic patients were examined by sodium dodecylsulfate polyacrylamide gel electrophoresis before and after oral retinoid (etretinate at a dose of 50 mg/day) treatment. Horny cell specimens were obtained from lesional, non‐lesional, and normal human skin of the back or thigh by scraping with scalpel and/or tape stripping before retinoid treatment. Horny cell specimens of healed‐lesional skin and retinoid‐affected skin were obtained by tape stripping because the horny cell layer was too thin to use a scalpel. α‐Keratins from lesional horny cells showed 3 major polypeptide bands with molecular weights (mw) of 53,000, 55,000, and 59,000 and some minor bands with mw of 62,000, 66,000, and less than 53,000. Non‐lesions showed two polypeptides (mw, 59,000 and 66,000) before treatment. After treatment, α‐keratins from horny cells of both non‐lesions and resolved lesions showed three polypeptides bands (mw, 59,000, 62,000, and 66,000).
Published Version
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