Effects of nucleoside (acid) antiviral drugs on improvement of liver indexes and prognosis of patients with decompensated hepatitis B cirrhosis

Abstract

Objective To observe the effects of nucleoside (acid) antiviral drugs on the improvement of liver indexes and prognosis of patients with decompensated hepatitis B cirrhosis. Methods Sixty-eight patients with decompensated hepatitis B cirrhosis who were treated from January 2010 to January 2011 were selected as the study subjects. The patients were randomly divided into the observation group and the control group, with 34 cases in each group. The control group was given routine treatment. The observation group was given nucleoside (acid) antiviral drug intervention in addition. The serum alanine aminotransferase(ALT), total bilirubin(TBIL), albumin(ALB), cholinesterase(CHE), prothrombin time(PT), Child-Pugh score and DNA HBV load of the two groups were detected. The improvement effects were compared between the two groups. Results ALT, TBIL, ALB, CHE, PT and Child-Pugh score in the observation group were better than those in the control group (P<0.05); DNA HBV load of the observation group [(1.89±1.23) log10 copy/ml] was lower than that of the control group [(5.43±1.12) log10 copy/ml] (P<0.05). In the observation group, there was no patient with liver cancer, while the incidence rate of liver cancer in the control group was 35.29% (P<0.05). Conclusions Nucleoside (acid) antiviral drugs can inhibit the replication of DNA HBV, reduce the degree of liver inflammation and the incidence of liver cancer, so as to effectively improve the liver function and prognosis of patients with decompensated hepatitis B cirrhosis. Key words: Nucleoside (acid) antiviral drugs; Decompensated period; Hepatitis B cirrhosis; Liver index; Prognosis