Effects of noninvasive positive pressure ventilation combined with ipratropium bromide intermittent inhalation on respiratory function and serum hs-CRP and IFN-γ levels in patients with severe bronchial asthma

Abstract

Objective To investigate the effects of noninvasive positive pressure ventilation combined with ipratropium bromide intermittent inhalation on respiratory function and serum hypersensitive C-reactive protein (hs-CRP), interferon-γ (IFN-γ) levels in patients with severe bronchial asthma (BA). Methods Eight-four patients with severe BA were randomly divided into control group and observation group, with 42 cases in each group. The control group was given conventional treatment regimen, and on the basis of this, the observation group was given noninvasive positive pressure ventilation combined with ipratropium bromide intermittent inhalation therapy additionally. Respiratory function [respiratory rate (RR), minute ventilation (MV), forced expiratory volume in one second (FEV1), forced expiratory volume (FVC)], serum hs-CRP, IFN-γ level, exhaled nitric oxide (FeNO) concentration and SF-36 quality of life score were compared between the two groups before and after treatment. Results ①Respiratory function: before treatment, there were no significant differences in RR, MV, FEV1 and FVC between the two groups (P>0.05); after treatment, the RR in observation group was significantly lower than that in control group, MV, FEV1 and FVC were significantly higher than those in control group (P 0.05); after treatment, serum hs-CRP in observation group was significantly lower than that in control group, and IFN-γ was significantly higher than that in control group (P 0.05); after treatment, the FeNO of both groups decreased, and FeNO in observation group was significantly lower than that in control group, the difference was statistically significant (P 0.05); after treatment, the SF-36 quality of life in observation group was significantly higher than that in control group (P<0.05). Conclusions Noninvasive positive pressure ventilation combined with ipratropium bromide intermittent inhalation therapy, in the treatment of severe BA, can effectively improve the respiratory function and serum hs-CRP and IFN-γ levels, has significant clinical effect, and can improve the quality of life. Key words: Severe bronchial asthma; Noninvasive positive pressure ventilation; Ipratropium bromide; Intermittent inhalation inhalation; Respiratory function