Abstract
Diabetes mellitus is one of the most prevalent metabolic disorders that affect people of all genders, ages, and races. Medicinal herbs have gained wide attention from researchers and have been considered to be a beneficial adjuvant agent to oral antidiabetic drugs because of their integrated effects. Concerning the various beneficial effects of Nigella sativa, this systematic review aims to provide comprehensive information on the effects of Nigella sativa on glucose and insulin profile status in humans. A computerized database search performed through Scopus and Medline via Ebscohost with the following set of keywords: Nigella Sativa OR black seed oil OR thymoquinone OR black cumin AND diabetes mellitus OR hyperglycemia OR blood glucose OR hemoglobin A1C had returned 875 relevant articles. A total of seven articles were retrieved for further assessment and underwent data extraction to be included in this review. Nigella sativa was shown to significantly improve laboratory parameters of hyperglycemia and diabetes control after treatment with a significant fall in fasting blood glucose, blood glucose level 2 h postprandial, glycated hemoglobin, and insulin resistance, and a rise in serum insulin. In conclusion, these findings suggested that Nigella sativa could be used as an adjuvant for oral antidiabetic drugs in diabetes control.
Highlights
Diabetes mellitus (DM) is one of the most prevalent metabolic disorders that occur throughout the world, which affects people of all genders, ages, and races
We reviewed the analysis of blood samples such as fasting blood glucose (FBG), blood glucose level 2 h postprandial (2hPG), glycated hemoglobin (HbA1c), as well as insulin level and insulin resistance
Increased insulin levels when combined with oral antidiabetic drug
Summary
Diabetes mellitus (DM) is one of the most prevalent metabolic disorders that occur throughout the world, which affects people of all genders, ages, and races. T2DM is characterized by the defect in insulin secretion, an action that causes an elevation in blood glucose levels. This elevation promotes the production of reactive oxygen species (ROS), which cause cellular damage that promote the development of diabetic complications, including diabetic retinopathy, nephropathy, and autonomic neuropathy [2,3]. Medicinal herbs have gained wide attention from researchers and have been considered to be a beneficial adjuvant agent to oral antidiabetic drugs because of their integrated effects [5,6]. NS is an annual herbaceous flowering plant, belonging to the Rununculaceae family which can be found mostly in Middle Eastern countries It is known as “black seed” or “kalonji” and has been widely used in food as spices and condiments.
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