Abstract
Nigella sativa (NS) has been shown to have antioxidant, anti-inflammatory and antiulcer activities in different conditions. The present work was done to investigate the possible effects of Nigella sativa aqueous extracts (NS) on gastric acid secretion in isolated rat stomach. Gastric acid secretion was measured in the isolated rat stomach preparation. The results obtained in vitro experiments showed that doses of 2 mg/100 ml DMSO and 5 mg/100 ml DMSO of NS aqueous extracts reduced gastric acid secretion stimulated by histamine and 5 mg/100 ml DMSO of NS aqueous extracts reduced gastric acid secretion stimulated by bethanechol, but none of the dosis of NS did affect pentagastrin-induced acid secretion. The present results suggest that NS has a gastroprotective effect, probably due to reducing gastric acid secretion.
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