Abstract
The effects of nicotine on the uptake and cellular distribution of 14C-norepinephrine ( 14C-NE)and 14C-dopamine ( 14C-DA) were examined in slices prepared from rat brain striatum and hypothalamus. Nicotine inhibited the uptake of both 14C-labelled norepinephrine and dopamine only in hypothalamus slices. Under similar incubation conditions, washout experiments with striatum and hypothalamus slices indicated that nicotine decreased the amount of 14C-NE and 14C-DA present in the slow washout component of the hypothalamus but did not alter 14C-labelled contents in the striatum. Addition of 0.62 mM nicotine produced a sustained increase in 14C-NE efflux from brain slices; the presence of desipramine or the absence of either sodium or calcium ions in the washout solution did not alter this nicotine-induced increase. These findings support the hypothesis that the nicotine-induced release of norepinephrine in the hypothalamus occurs by a specific and direct action at cellular amine binding sites or stores.
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