Abstract
The synthesis of catecholamines from [3H]tyrosine was studied in slices of six regions of mouse brain following footshock or ACTH injection. Immediately following a 30 minute period of footshock, there was an activation of the accumulation of [3H]DA in slices of frontal cortex. No change in the accumulation of [3H]DA was observed in slices of striatum or hypothalamus, nor of [3H]NE in slices of frontal cortex, hippocampus, hypothalamus, cerebellum, or brain stem. Thus the effect on frontal cortex DA was both regionally and catecholamine specific. Similar results were obtained with footshock treatment of adrenalectomized mice. However, dexamethasone pretreatment prevented a significant change in frontal cortex [3H]DA accumulation, but resulted in a footshock-induced increase in [3H]NE accumulation in slices of both brain stem and hypothalamus. When footshock treatment was repeated once a day for five days, and slices prepared on the sixth day, frontal cortex [3H]DA accumulation was not increased. However, the accumulation of [3H]NE in slices of hypothalamus (but not frontal cortex, hippocampus or brain stem) was increased.
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