Effects of nesfatin-1 on energy expenditure

Abstract

Event Abstract Back to Event Effects of nesfatin-1 on energy expenditure K. Könczöl1, D. Zelena2, O. Pintér2, J. Varga2, M. Palkovits1 and Z. E. Tóth1* 1 Semmelweis University and the Hungarian Academy of Sciences, Department of Anatomy, Histology and Embriology, Hungary 2 Hungarian Academy of Sciences, Institute of Experimental Medicine, Hungary Nesfatin-1 is an anorexigenic peptide, reduces food intake, and plays a role in stress reaction. To investigate other functions mediated by nesfatin-1 and examine the time course of effects, we performed telemetric experiments and measured food intake, core body temperature, locomotor activity, and heart rate (HR) of rats for 48 h after icv administration of 25pmol nesfatin-1. Nesfatin-1 reduced nocturnal food intake for 2 days applied either during the day or at night. Nesfatin-1 raised body temperature immediately after nighttime application, and produced a small and belated elevation applied during the day. In both cases, body temperature of treated rats was markedly higher than that of controls during the light phases of the 48h lasting observation period, together with a reduced amplitude of the diurnal temperature rhythm. After daytime drug application HR elevated transiently. There was no change in locomotion. Serotonin and thyrotropin-releasing hormon (TRH) expressing caudal raphe neurons may act as premotor neurons that activate autonomic preganglionic efferents and regulate heat production in brown adipose tissue in rats. We colocalised nesfatin-1 and TRH in neurons of nucleus raphe pallidus and obscurus suggesting a possible site for nesfatin-1 to interact with the thermoregulatory system. In summary, nesfatin-1 has a long term influence on energy expenditure by reducing food intake and affecting heat production. Acknowledgements Supported by: NKTH-OTKA 80180 (M. P.), ETT 495/09 and the Bolyai fellowship (Tóth ZE). Keywords: Neuroendocrinology, Neuroscience Conference: 13th Conference of the Hungarian Neuroscience Society (MITT), Budapest, Hungary, 20 Jan - 22 Jan, 2011. Presentation Type: Abstract Topic: Neuroendocrinology Citation: Könczöl K, Zelena D, Pintér O, Varga J, Palkovits M and Tóth ZE (2011). Effects of nesfatin-1 on energy expenditure. Front. Neurosci. Conference Abstract: 13th Conference of the Hungarian Neuroscience Society (MITT). doi: 10.3389/conf.fnins.2011.84.00162 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 03 Mar 2011; Published Online: 23 Mar 2011. * Correspondence: Dr. Z. E Tóth, Semmelweis University and the Hungarian Academy of Sciences, Department of Anatomy, Histology and Embriology, Budapest, Hungary, etn@freemail.hu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers K. Könczöl D. Zelena O. Pintér J. Varga M. Palkovits Z. E Tóth Google K. Könczöl D. Zelena O. Pintér J. Varga M. Palkovits Z. E Tóth Google Scholar K. Könczöl D. Zelena O. Pintér J. Varga M. Palkovits Z. E Tóth PubMed K. Könczöl D. Zelena O. Pintér J. Varga M. Palkovits Z. E Tóth Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.