Glutamatergic and GABAergic innervation of GnRH neurons in the human hypothalamus

Abstract

Event Abstract Back to Event Glutamatergic and GABAergic innervation of GnRH neurons in the human hypothalamus E. Hrabovszky1*, C. S. Molnár1, I. Kallo2, B. Borsay3, L. Sarkadi3, L. Herczeg3, M. Watanabe4 and Z. Liposits1, 2 1 Hungarian Academy of Sciences, Institute of Experimental Medicine, Hungary 2 Pázmány Péter Catholic University, Department of Neuroscience, Hungary 3 University of Debrecen, Department of Forensic Medicine, Hungary 4 Hokkaido University School of Medicine, Department of Anatomy, Japan Neurosecretory projections of gonadotropin-releasing hormone (GnRH) neurons to the hypophysial portal capillaries represent the final common output way of the hypothalamus in the neuroendocrine control of reproduction. GnRH neurons receive afferent input from a variety of neurotransmitter systems which are only partly characterized in the human. In the present study we used immunohistochemical approaches to address the contribution of the amino acid neurotransmitters GABA and glutamate to the afferent regulation of human GnRH neurons. According to previous findings in rodents where GABA represents the main neurotransmitter in the afferent control of GnRH neurons, we found that vesicular GABA transporter-immunoreactive GABAergic axons abundantly innervated the cell bodies and the dendrites of human GnRH neurons. While in rats, only glutamatergic axons of the VGLUT2 phenotype innervate GnRH neurons, in human samples we observed both VGLUT1- and VGLUT2 immunoreactive afferent contacts on GnRH neurons, with a preferential accumulation on GnRH dendrites. These morphological observations implicate the classic amino acid neurotransmitters GABA and glutamate in the afferent regulation of human GnRH neurons. As in rodents, GABA-ergic and glutamatergic afferents may have important contributions to metabolic-, sex steroid-, circadian- and stress signaling to the reproductive axis. Acknowledgements Supported by: OTKA K69127, T73002 and K83710; ETT 122/2009; FP7/2007-2013 (n° 245009) Keywords: Neuroendocrinology, Neuroscience Conference: 13th Conference of the Hungarian Neuroscience Society (MITT), Budapest, Hungary, 20 Jan - 22 Jan, 2011. Presentation Type: Abstract Topic: Neuroendocrinology Citation: Hrabovszky E, Molnár CS, Kallo I, Borsay B, Sarkadi L, Herczeg L, Watanabe M and Liposits Z (2011). Glutamatergic and GABAergic innervation of GnRH neurons in the human hypothalamus. Front. Neurosci. Conference Abstract: 13th Conference of the Hungarian Neuroscience Society (MITT). doi: 10.3389/conf.fnins.2011.84.00141 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 03 Mar 2011; Published Online: 23 Mar 2011. * Correspondence: Dr. E. Hrabovszky, Hungarian Academy of Sciences, Institute of Experimental Medicine, Budapest, Hungary, hrabovszky.erik@koki.mta.hu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers E. Hrabovszky C. S Molnár I. Kallo B. Borsay L. Sarkadi L. Herczeg M. Watanabe Z. Liposits Google E. Hrabovszky C. S Molnár I. Kallo B. Borsay L. Sarkadi L. Herczeg M. Watanabe Z. Liposits Google Scholar E. Hrabovszky C. S Molnár I. Kallo B. Borsay L. Sarkadi L. Herczeg M. Watanabe Z. Liposits PubMed E. Hrabovszky C. S Molnár I. Kallo B. Borsay L. Sarkadi L. Herczeg M. Watanabe Z. Liposits Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.